HCID 66631372, compound → HCID 66630811, compound

HRID 544839Notes

Reaction equation

HRID 544839 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][C:7]([N:10]2[CH:16]3[CH2:17][CH2:18][N:13]([CH2:14][CH2:15]3)[CH2:12][CH2:11]2)=[N:8][CH:9]=1)([O-])=O>[Pd].CO>[N:13]12[CH2:14][CH2:15][CH:16]([CH2:17][CH2:18]1)[N:10]([C:7]1[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][N:6]=1)[CH2:11][CH2:12]2

Participants

4

Reactant 1

HCID 66631372HCID 66631372, compound

Product 1

HCID 66630811HCID 66630811, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 4-(5-nitro-pyrimidin-2-yl)-1,4-diaza-bicyclo[3.2.2]nonane (0.71 g, 2.85 mmol), palladium (0.25 g, 10% on activated carbon) and methanol (50 ml) was stirred under hydrogen for 10 min. The reaction-mixture was filtered through celite and was washed with ethanol (50 ml). The product was dried and evaporated. Yield 100%.

Workup

  1. filtrationThe reaction-mixture was filtered through celite
  2. washwas washed with ethanol (50 ml)
  3. customThe product was dried
  4. customevaporated

Sources & evidence

ORD record
ord-c0d72b5517c04980ad3a1b527bdd1757
Source dataset
uspto-grants-2011_05
Patent number
US07935695B2

Reaction notes

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