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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 544934Generated: October 28, 2026

3-Pyridinylboronic acid → N-(5-(Cyclopropylcarbamoyl)-2-methylphenyl)-3-methyl-4-(pyridin-3-yl)thiophene-2-carboxamide

https://huagongshe.com/reaction/544934

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Pyridinylboronic acidHCID 2734378—
Reactant4-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-3-methylthiophene-2-carboxamideHCID 59761512—
ProductN-(5-(Cyclopropylcarbamoyl)-2-methylphenyl)-3-methyl-4-(pyridin-3-yl)thiophene-2-carboxamideHCID 24985753—

Reaction Steps

The title compound was prepared by coupling 4-bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-3-methylthiophene-2-carboxamide with commercially available 3-pyridylboronic acid using the method described in Step B of Example 136 to afford a white solid (Example 198). HPLC Ret time=1.98 min. LCMS [M+H]+ 392.29.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07935696B2
Source datasetuspto-grants-2011_05
ORD IDord-1ea54dc0561945f2849d123f597e1116
Source noteuspto-grants-2011_05