Benzyl Bromide → 1-Benzyl-8-chloro-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

HRID 544990Notes

Reaction equation

HRID 544990 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11](=[O:12])[CH2:10][CH2:9][C:8](=[O:13])[NH:7][C:6]=2[CH:14]=1.[CH2:15](Br)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH2:15]([N:7]1[C:8](=[O:13])[CH2:9][CH2:10][C:11](=[O:12])[C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:14][C:6]1=2)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 11390173HCID 11390173, compound

Product 1

HCID 669346751-Benzyl-8-chloro-3,4-dihydro-1H-benzo[b]azepine-2,5-dioneYield 38%

Procedure

In a manner similar to that described for Method W, 8-chloro-3,4-dihydro-1H-benzo[b]azepine-2,5-dione and benzyl bromide were converted to the title compound (38%): MS m/z=300 (M+H).

Sources & evidence

ORD record
ord-cde70c1ead3b408cb86e0ea5d1b6b4b2
Source dataset
uspto-grants-2011_05
Patent number
US07935694B2

Reaction notes

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