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HRID545029

反应详情

EQUATION

反应方程式

HRID 545029 的结构方程式

REACTANTS

反应物

3
结构：C#C[Si](C)(C)C
HCID66111

Trimethylsilylacetylene

C5H10Si

结构：O=C1Cc2cnc(Nc3ccc(I)cc3)nc2-c2ccc(Cl)cc2N1
HCID56946588

未命名化合物

结构：C[Si](C)(C)C#Cc1ccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2NC(=O)C3)cc1
HCID66934690

未命名化合物

PRODUCTS

生成物

1
结构：C#Cc1ccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2NC(=O)C3)cc1
HCID59851036

未命名化合物

PROCEDURE

实验过程

In a manner similar to that described for Method O, 9-chloro-2-(4-iodo-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one (I-36) and ethynyltrimethylsilane were converted to 9-chloro-2-(4-trimethylsilanylethynyl-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one, which was deprotected in a manner similar to I-33 to give I-45 (38%): HRMS Calcd. for C20H13ClN4O: 361.0856, Found 361.0848.

WORKUP

后处理

  1. customto give I-45 (38%)