反应详情

To a stirring solution of 2-{3-[9-chloro-2-(3,4-dimethoxy-phenylamino)-6-oxo-5,6-dihydrobenzo[b]pyrimido[4,5-d]azepin-7-yl]-propyl}-isoindole-1,3-dione (I-40-c) (51 mg, 0.09 mmol) in ethanol (1.5 mL) was added methylamine (40% by wt in H2O, 0.5 mL). After stirring for 2.5 h at room temperature, the solution was diluted with dichloromethane and washed with water. The organics were dried over magnesium sulfate and concentrated. Preparative HPLC gave I-40: MS Rt=1.32 min. m/z=454 (M+H).

1. washwashed with water
2. dry with materialThe organics were dried over magnesium sulfate
3. concentrationconcentrated
4. customPreparative HPLC gave