反应详情

Heat a mixture of 2-methoxy-3-trifluoromethyl-pyridine (1.0 g, 5.6 mmol) and 30% HBr in acetic acid (5 mL) at reflux for 1 hour. Cool the mixture and remove the volatiles by rotary evaporation. Add ether and collect the precipitate by filtration. Air-dry to give the title compound as the hydrogen bromide salt.

1. temperatureHeat
2. temperatureat reflux for 1 hour
3. temperatureCool the mixture
4. customremove the volatiles
5. customby rotary evaporation
6. customAdd ether and collect the precipitate
7. filtrationby filtration
8. customAir-dry