反应详情

To 3-trifluoromethyl-pyridin-2-ol (1.63 g, 10 mmol) in concentrated sulfuric acid at 0° C., add dropwise fuming nitric acid (2 mL). Stir the mixture at room temperature for 3 hours and pour onto ice. Collect the precipitate by filtration, air-dry and finally dry in a vacuum oven overnight to give the title compound as a white solid.

1. additionpour onto ice
2. customCollect the precipitate
3. filtrationby filtration
4. customair-dry
5. customfinally dry in a vacuum oven overnight