反应详情

Heat a mixture of 5-nitro-3-trifluoromethyl-pyridin-2-ol (416 mg, 2.0 mmol) and phosphorus oxychloride (1 mL) at 85° C. for 18 hours. Cool the mixture and remove the volatiles by rotary evaporation. Dissolve the residue in EtOAc (15 mL) and wash with water (10 mL), saturated NaHCO3(aq) (10 mL) and brine (10 mL). Dry the organic extract over MgSO4 and remove the solvent under reduced pressure to yield the title compound.

1. temperatureHeat
2. temperatureCool the mixture
3. customremove the volatiles
4. customby rotary evaporation
5. dissolutionDissolve the residue in EtOAc (15 mL)
6. washwash with water (10 mL), saturated NaHCO3(aq) (10 mL) and brine (10 mL)
7. customDry the
8. extractionorganic extract over MgSO4
9. customremove the solvent under reduced pressure