反应详情

Dissolve 1-(5-bromo-3-(trifluoromethyl)pyridin-2-yl)ethanol (3.75 g, 0.01394 moles) in anhydrous THF (75 mL) and add MnO2 (12.1-24.2 g, 10 to 20 eq) at room temperature. Reflux the mixture under N2 atmosphere for 3 days. Cool the reaction mixture, filter through celite, wash the celite with THF (3×50 mL) and then concentrate under vacuum to afford the title compound as a colorless yellow oil.

1. temperatureReflux the mixture under N2 atmosphere for 3 days
2. temperatureCool the reaction mixture
3. filtrationfilter through celite
4. washwash the celite with THF (3×50 mL)
5. concentrationconcentrate under vacuum