HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 19959422, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 2-Bromo-1-(5-chloropyridin-2-yl)ethan-1-one hydrobromide | HCID 19959414 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 19959422 | HCID 19959422 | — |
Reaction Steps
15 g of 2-bromoacetyl-5-chloropyridine hydrobromide are dissolved in 50 ml of dry dichloromethane, 9.7 g of imidazole are added and the mixture is stirred for 24 hours at room temperature. Evaporation of the solvent in vacuo and subsequent chromatography of the residue over silicagel (dichloromethane/methanol/heptane=7/1/4) yield the compound as a cream coloured solid; m.p.: 122°-129°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05622982 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-d144c05ae6ae4a7bbc14d81edc48c273 |
| Source note | uspto-grants-1997_04 |