Thiourea → HCID 178472262, compound

HRID 545123Notes

Reaction equation

HRID 545123 reaction equation
Cl[C:2]1[N:11]=[C:10]([CH:12]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:9]2[C:4](=[CH:5][C:6]([O:25][CH3:26])=[C:7]([O:23][CH3:24])[CH:8]=2)[N:3]=1.NC(N)=[S:29]>C(O)C>[CH2:16]([O:15][C:13]([CH:12]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:10]1[C:9]2[C:4](=[CH:5][C:6]([O:25][CH3:26])=[C:7]([O:23][CH3:24])[CH:8]=2)[N:3]=[C:2]([SH:29])[N:11]=1)=[O:14])[CH3:17]

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 86616377HCID 86616377, compound

Product 1

HCID 178472262HCID 178472262, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The resultant product (600 mg) of (166-1) and thiourea (250 mg) were dissolved in ethanol (100 mL), and the mixture was heated under reflux for 48 hrs. The yellow solid precipitated in the reaction mixture was collected by filtration and washed with water and ethyl acetate to give the title compound (500 mg) as a yellow solid.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 48 hrs
  3. customThe yellow solid precipitated in the reaction mixture
  4. filtrationwas collected by filtration
  5. washwashed with water and ethyl acetate

Sources & evidence

ORD record
ord-0cce5a6b182f449ea59565a673321950
Source dataset
uspto-grants-2011_05
Patent number
US07935700B2

Reaction notes

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