反应详情

2.0 mL of 5N NaOHaq was added to a solution of 1.10 g of methyl 4-ethoxy-8-cyclopropylquinoline-2-carboxylate in 5 mL of CHCl3/MeOH (1:1) and the mixture was stirred at room temperature for 3 hr. After the addition of 3.0 mL of 5N HCl aq, the mixture was extracted by CHCl3. The organic layer was washed by satd. brine, dried over NaSO4, then concentrated to afford 4-ethoxy-8-cyclopropylquinoline-2-carboxylic acid as a colorless solid.

1. extractionthe mixture was extracted by CHCl3
2. washThe organic layer was washed by satd
3. dry with materialbrine, dried over NaSO4
4. concentrationconcentrated