Thiomorpholine → HCID 67171237, compound

HRID 545234Notes

Reaction equation

HRID 545234 reaction equation
[NH:1]1[CH2:6][CH2:5][S:4][CH2:3][CH2:2]1.[N+:7]([C:10]1[CH:11]=[CH:12][C:13](F)=[C:14]([CH3:16])[CH:15]=1)([O-:9])=[O:8].C(N(CC)C(C)C)(C)C>CS(C)=O>[CH3:16][C:14]1[CH:15]=[C:10]([N+:7]([O-:9])=[O:8])[CH:11]=[CH:12][C:13]=1[N:1]1[CH2:6][CH2:5][S:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 67164ThiomorpholineHCID 68001Benzene, 1-fluoro-2-methyl-4-nitro-HCID 81531Diisopropylethylamine

Product 1

HCID 67171237HCID 67171237, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In the same manner as in Production Example 5-1, but using thiomorpholine in place of N-ethylpiperazine used in Production Example 5-1, using 5-nitro-2-fluorotoluene in place of 2-fluoro-5-nitrobenzyl alcohol, using N,N-diisopropylethylamine in place of potassium carbonate, and using dimethylsulfoxide in place of N-methylpyrrolidone, crude 4-(2-methyl-4-nitrophenyl)thiomorpholine was obtained.

Sources & evidence

ORD record
ord-ae48a6fed7e540fdbbce76b1dc7aee11
Source dataset
uspto-grants-2011_05
Patent number
US07935708B2

Reaction notes

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