Benzene, 1-fluoro-2-methyl-4-nitro- → HCID 43373591, compound

HRID 545237Notes

Reaction equation

HRID 545237 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([NH2:8])[CH2:4][CH2:3]1.F[C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][C:11]=1[CH3:19]>CS(C)=O>[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([NH:8][C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][C:11]=2[CH3:19])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 68001Benzene, 1-fluoro-2-methyl-4-nitro-HCID 27375314-Amino-1-methylpiperidine

Product 1

HCID 43373591HCID 43373591, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In the same manner as in Production Example 5-1 but using 1-methylpiperidine-4-amine in place of N-ethylpiperazine used in Production Example 5-1, using 2-fluoro-5-nitrotoluene in place of 2-fluoro-5-nitrobenzyl alcohol and using dimethylsulfoxide in place of N-methylpyrrolidone, 1.2 g of the entitled compound was obtained as a yellow solid.

Sources & evidence

ORD record
ord-0b4227f2eea6469186d685859530e664
Source dataset
uspto-grants-2011_05
Patent number
US07935708B2

Reaction notes

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