反应详情

In a nitrogen atmosphere with cooling with ice, 5.29 mL of 3′-bromoacetophenone was added to 25 mL of 2 M methylmagnesium iodide/diethyl ether solution and 100 mL of diethyl ether, and stirred for 20 minutes. Water and 2 N hydrochloric acid were added to the reaction liquid, extracted with ethyl acetate, washed with aqueous saturated sodium hydrogencarbonate solution and saturated saline water, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure to obtain crude 2-(3-bromophenyl)propan-2-ol.

1. extractionextracted with ethyl acetate
2. washwashed with aqueous saturated sodium hydrogencarbonate solution and saturated saline water
3. dry with materialdried with anhydrous magnesium sulfate
4. customThe solvent was evaporated away under reduced pressure