Water → HCID 63961722, compound

HRID 545253Notes

Reaction equation

HRID 545253 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.[OH2:9]>>[Br:8][C:4]1[N:3]=[C:2]([N:3]([CH3:4])[CH2:2][CH2:7][OH:9])[CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 962WaterHCID 122742,6-Dibromopyridine

Product 1

HCID 63961722HCID 63961722, compound

Procedure

7.45 g of 2,6-dibromopyridine and 12 mL of N-methylethanol were stirred overnight at 140° C. Water was added to the reaction liquid, extracted with ethyl acetate, washed with saturated saline water, and dried with anhydrous magnesium sulfate. After concentrated under reduced pressure, the residue was purified through silica gel column chromatography (hexane/ethyl acetate=1/1) to obtain 3.98 g of the entitled compound as a colorless oily substance.

Workup

  1. extractionextracted with ethyl acetate
  2. washwashed with saturated saline water
  3. dry with materialdried with anhydrous magnesium sulfate
  4. concentrationAfter concentrated under reduced pressure
  5. customthe residue was purified through silica gel column chromatography (hexane/ethyl acetate=1/1)

Sources & evidence

ORD record
ord-8b2cb176f46145e69e5f87966d8fc5da
Source dataset
uspto-grants-2011_05
Patent number
US07935708B2

Reaction notes

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