Ethanol → 5-Iodo-4-(1-methylhydrazino)-2-methylthiopyrimidine

HRID 545270Notes

Reaction equation

HRID 545270 reaction equation
C(=O)([O-])[O-].[K+].[K+].C(O)C.Cl[C:11]1[C:16]([I:17])=[CH:15][N:14]=[C:13]([S:18][CH3:19])[N:12]=1.[CH3:20][NH:21][NH2:22]>O>[I:17][C:16]1[C:11]([N:21]([CH3:20])[NH2:22])=[N:12][C:13]([S:18][CH3:19])=[N:14][CH:15]=1

Participants

6

Reactant 4

HCID 702EthanolHCID 6061MethylhydrazineHCID 11430Potassium CarbonateHCID 136365194-Chloro-5-iodo-2-(methylthio)pyrimidine

Product 1

HCID 223239775-Iodo-4-(1-methylhydrazino)-2-methylthiopyrimidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

603 mg of potassium carbonate was added to ethanol (15 mL) solution of 1.25 g of 4-chloro-5-iodo-2-(methylthio)pyrimidine, and with cooling with ice, 0.28 mL of methylhydrazine was dropwise added thereto. This was stirred overnight at room temperature, then water was added thereto, and the precipitated crystal was taken out through filtration and dried to obtain 851 mg of the entitled compound as a white solid.

Workup

  1. additionwas dropwise added
  2. filtrationthe precipitated crystal was taken out through filtration
  3. customdried

Sources & evidence

ORD record
ord-3c11093a21044193a80f67683a9f7cbf
Source dataset
uspto-grants-2011_05
Patent number
US07935708B2

Reaction notes

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