反应详情

213 mg of ethyl 1,6-dimethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxyl ate and 78 mg of 3-amino-1,2,4-triazole were added to 2.5 ml of bromobenzene, then, the mixture was stirred for 7.5 hours under heat refluxing condition. The reaction mixture was cooled to room temperature. The resulting solid was collected by filtration, and washed with a mixed solvent of t-butyl methyl ether and hexane and dried to obtain 188 mg of 1,6-dimethyl-4-hydroxy-2-oxo-N-(1,2,4-triazol-3-yl)-1,2-dih ydropyridine-3-carboxamide (hereinafter, referred to as present compound 23) represented by the formula:

1. temperatureunder heat
2. temperaturerefluxing condition
3. filtrationThe resulting solid was collected by filtration
4. washwashed with a mixed solvent of t-butyl methyl ether and hexane
5. customdried