HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Cyclopropylamino-3-oxo-butyric acid ethyl ester hydrochloride salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 2-(tert-Butoxycarbonyl-cyclopropyl-amino)-3-oxo-butyric acid ethyl ester | HCID 67133193 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Cyclopropylamino-3-oxo-butyric acid ethyl ester hydrochloride salt | HCID 67133059 | 70% |
Reaction Steps
To 6.4 g (23 mmol) of 2-(tert-butoxycarbonyl-cyclopropyl-amino)-3-oxo-butyric acid ethyl ester was added 10 ml of 4M hydrochloric acid in dioxane and the mixture stirred for 2 h. Diethyl ether was then added and 3.5 g (70%) of product was isolated by filtration. MS: 186.0 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935707B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-80acbbb4720e48338e4020e9422a3588 |
| Source note | uspto-grants-2011_05 |