Hydrochloric Acid → 2-Cyclopropylamino-3-oxo-butyric acid ethyl ester hydrochloride salt

HRID 545357Notes

Reaction equation

HRID 545357 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[CH:5]([N:9](C(OC(C)(C)C)=O)[CH:10]1[CH2:12][CH2:11]1)[C:6](=[O:8])[CH3:7])[CH3:2].[ClH:21].C(OCC)C>O1CCOCC1>[ClH:21].[CH2:1]([O:3][C:4](=[O:20])[CH:5]([NH:9][CH:10]1[CH2:11][CH2:12]1)[C:6](=[O:8])[CH3:7])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 671331932-(tert-Butoxycarbonyl-cyclopropyl-amino)-3-oxo-butyric acid ethyl ester

Product 1

HCID 671330592-Cyclopropylamino-3-oxo-butyric acid ethyl ester hydrochloride saltYield 70%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 6.4 g (23 mmol) of 2-(tert-butoxycarbonyl-cyclopropyl-amino)-3-oxo-butyric acid ethyl ester was added 10 ml of 4M hydrochloric acid in dioxane and the mixture stirred for 2 h. Diethyl ether was then added and 3.5 g (70%) of product was isolated by filtration. MS: 186.0 (MH+).

Sources & evidence

ORD record
ord-80acbbb4720e48338e4020e9422a3588
Source dataset
uspto-grants-2011_05
Patent number
US07935707B2

Reaction notes

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