反应详情

温度

50 °C

A solution of 2.80 g (8.0 mmol) of [5-bromo-3-methyl-2-(3-trifluoromethoxy-phenyl)-3H-imidazol-4-yl]-methanol in 120 ml of EtOAc was treated in small portions with 4.85 g (55.8 mmol) of manganese(IV) oxide; the reaction mixture was stirred at RT for 2 hours and at 50° C. for 5 hours, it was then cooled down to RT and filtered (with the aid of dicalite) and the solvents were evaporated to give 2.813 g (quant.) of the title compound as colorless oil. MS: 349.0 (MH+, 1Br).

1. temperatureit was then cooled down to RT
2. filtrationfiltered (with the aid of dicalite) and the solvents
3. customwere evaporated