Trimethylsilylacetylene → HCID 57541083, compound

HRID 545398Notes

Reaction equation

I[C:2]1[N:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=2)[N:4]([CH3:17])[C:3]=1[C:18]([N:20]1[CH2:25][CH2:24][CH:23]([N:26]2[CH2:30][CH2:29][CH2:28][CH2:27]2)[CH2:22][CH2:21]1)=[O:19].[CH3:31][Si:32]([C:35]#[CH:36])([CH3:34])[CH3:33]>>[CH3:17][N:4]1[C:3]([C:18]([N:20]2[CH2:25][CH2:24][CH:23]([N:26]3[CH2:30][CH2:29][CH2:28][CH2:27]3)[CH2:22][CH2:21]2)=[O:19])=[C:2]([C:36]#[C:35][Si:32]([CH3:34])([CH3:33])[CH3:31])[N:6]=[C:5]1[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1

Participants

Reactant 2

HCID 66111Trimethylsilylacetylene

HCID 57541097HCID 57541097, compound

Product 1

HCID 57541083HCID 57541083, compound

Procedure

In analogy to the procedure described for example 12, [5-iodo-3-methyl-2-(3-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 36) was reacted with trimethylsilylacetylene to give the title compound as brown oil. MS: 503.3 (MH+).

Sources & evidence

ORD record: ord-3e611452d95a492bb7fde9d022add260
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07935707B2

Reaction notes

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