Potassium Carbonate → HCID 25152483, compound

HRID 545399Notes

Reaction equation

[CH3:1][N:2]1[C:6]([C:7]([N:9]2[CH2:14][CH2:13][CH:12]([N:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)[CH2:11][CH2:10]2)=[O:8])=[C:5]([C:20]#[C:21][Si](C)(C)C)[N:4]=[C:3]1[C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=1.C(=O)([O-])[O-].[K+].[K+]>>[C:20]([C:5]1[N:4]=[C:3]([C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:33])[F:34])[CH:27]=2)[N:2]([CH3:1])[C:6]=1[C:7]([N:9]1[CH2:10][CH2:11][CH:12]([N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:13][CH2:14]1)=[O:8])#[CH:21]

Participants

Reactant 2

HCID 11430Potassium Carbonate

HCID 57541083HCID 57541083, compound

Product 1

HCID 25152483HCID 25152483, compound

Procedure

In analogy to the procedure described for example 13, [3-methyl-2-(3-trifluoromethyl-phenyl)-5-trimethylsilanylethynyl-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 40) was reacted with potassium carbonate to give the title compound as yellow oil. MS: 431.4 (MH+).

Sources & evidence

ORD record: ord-d77f5c8fbaf940c392343fc9f8a5ed58
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07935707B2

Reaction notes

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