HRID545426

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66901590

未命名化合物

2 次

结构：Cn1c(-c2cccc(C(F)(F)F)c2)nc(Cl)c1C(=O)O

HCID67133025

未命名化合物

结构：Cn1c(-c2cccc(C(F)(F)F)c2)nc(Cl)c1C(=O)N1CCC(N2CCC[C@H]2COC(=O)c2ccccc2)CC1

HCID67133115

未命名化合物

PRODUCTS

生成物

结构：Cn1c(-c2cccc(C(F)(F)F)c2)nc(Cl)c1C(=O)N1CCC(N2CCC[C@H]2CO)CC1

HCID57541137

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described for example 73, benzoic acid (S)-1-{1-[5-chloro-3-methyl-2-(3-trifluoromethyl-phenyl)-3H-imidazole-4-carbonyl]-piperidin-4-yl}-pyrrolidin-2-ylmethyl ester [prepared in analogy to the procedure described for example 2 from 5-chloro-3-methyl-2-(3-trifluoromethyl-phenyl)-3H-imidazole-4-carboxylic acid (example 74) and benzoic acid (S)-1-piperidin-4-yl-pyrrolidin-2-ylmethyl ester (intermediate 6C)] has been saponified to give the title compound as colorless amorphous solid. MS: 471.2 (MH+, 1Cl).

WORKUP

后处理

customprepared in analogy to the procedure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c16ace0d0e004daca6887c00c468af95
来源数据集: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07935707B2
来源说明: uspto-grants-2011_05

反应 SMILES

[Cl:1][C:2]1[N:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=2)[N:4]([CH3:17])[C:3]=1[C:18]([N:20]1[CH2:25][CH2:24][CH:23]([N:26]2[CH2:30][CH2:29][CH2:28][C@H:27]2[CH2:31][O:32]C(=O)C2C=CC=CC=2)[CH2:22][CH2:21]1)=[O:19].ClC1N=C(C2C=CC=C(C(F)(F)F)C=2)N(C)C=1C(O)=O.N1CCC(N2CCC[C@H]2COC(=O)C2C=CC=CC=2)CC1>>[Cl:1][C:2]1[N:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=2)[N:4]([CH3:17])[C:3]=1[C:18]([N:20]1[CH2:25][CH2:24][CH:23]([N:26]2[CH2:30][CH2:29][CH2:28][C@H:27]2[CH2:31][OH:32])[CH2:22][CH2:21]1)=[O:19]