benzoic acid (S)-1-piperidin-4-yl-pyrrolidin-2-ylmethyl ester → [5-Chloro-3-methyl-2-(3-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-[4-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-methanone

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Reaction Steps

In analogy to the procedure described for example 73, benzoic acid (S)-1-{1-[5-chloro-3-methyl-2-(3-trifluoromethyl-phenyl)-3H-imidazole-4-carbonyl]-piperidin-4-yl}-pyrrolidin-2-ylmethyl ester [prepared in analogy to the procedure described for example 2 from 5-chloro-3-methyl-2-(3-trifluoromethyl-phenyl)-3H-imidazole-4-carboxylic acid (example 74) and benzoic acid (S)-1-piperidin-4-yl-pyrrolidin-2-ylmethyl ester (intermediate 6C)] has been saponified to give the title compound as colorless amorphous solid. MS: 471.2 (MH+, 1Cl).

Provenance & Evidence