HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Methyl 4-[(6-methoxy-2-naphthyl)methyl]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | Methyl 4-[(RS)-hydroxy(6-methoxy-2-naphthyl)methyl]benzoate | HCID 67203038 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | Methyl 4-[(6-methoxy-2-naphthyl)methyl]benzoate | HCID 67204017 | — |
Reaction Steps
The title compound of Example 1, Step A (0.97 g, 3 mmol) was treated with 50 mL of chloroform containing 3% each of TFA and triethylsilane for 2 h. The reaction was partitioned between aq sodium bicarbonate and EtOAc. The organic phase was concentrated and the resultant residue was purified by flash chromatography on silica gel (mobile phase=15:85 (v/v) EtOAc:hexanes) to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935713B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-e4502f952a3a469f89194e5443668de9 |
| Source note | uspto-grants-2011_05 |