Methanesulfonyl chloride → HCID 11486101, compound

HRID 545491Notes

Reaction equation

[OH:1][NH:2][C:3]([C:5]1[S:9][C:8]2[CH:10]=[C:11]([CH2:14][N:15](C(=O)C)[CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:12]=[CH:13][C:7]=2[CH:6]=1)=[O:4].[CH3:26][S:27](Cl)(=[O:29])=[O:28]>>[OH:1][NH:2][C:3]([C:5]1[S:9][C:8]2[CH:10]=[C:11]([CH2:14][N:15]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[S:27]([CH3:26])(=[O:29])=[O:28])[CH:12]=[CH:13][C:7]=2[CH:6]=1)=[O:4]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 11473695HCID 11473695, compound

Product 1

HCID 11486101HCID 11486101, compound

Procedure

The title compound was prepared in procedures similar to those described for the preparation of 6-[(acetyl-benzyl-amino)-methyl]-benzo[b]thiophene-2-carboxylic acid hydroxyamide. Methanesulfonyl chloride was used instead of acetic anhydride for the preparation of this title compound. 1H NMR (DMSO-d6, 200 MHz) δ 11.46 (brs, 1H), 9.29 (brs, 1H), 7.90-7.76 (m, 3H), 7.36-7.16 (m, 6H), 4.43 (s, 2H), 4.33 (s, 2H), 2.99 (s, 3H). MS (EI): cal'd 389.1 (M−H−), exp 389.2 (M−H−).

Workup

customThe title compound was prepared in procedures similar to

Sources & evidence

ORD record: ord-cee531546e9a429a83ba26bba457c134
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07935724B2

Reaction notes

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