反应详情

To a mixture of 4-(2-hydroxyethyl)piperidine (5.0 g) and triethylamine (5.39 ml) in methylene chloride (50 ml) was added dropwise a solution of 3-methoxybenzoyl chloride (5.44 ml) in methylene chloride (15 ml) at 0° C. After stirring at ambient temperature for 1 hour, the mixture was poured into water and extracted with ethyl acetate. The extract was washed with water and brine, and dried over magnesium sulfate, and evaporated in vacuo. The residue was chromatographed on silica eluting with chloroform and the fractions containing the object product were collected and evaporated to give 2-[1-(3-methoxybenzoyl)piperidin-4-yl]ethanol (9.6 g) as an oil.

1. extractionextracted with ethyl acetate
2. washThe extract was washed with water and brine
3. dry with materialdried over magnesium sulfate
4. customevaporated in vacuo
5. customThe residue was chromatographed on silica eluting with chloroform
6. additionthe fractions containing the object product
7. customwere collected
8. customevaporated