(4-Bromo-3-fluorophenyl)hydrazine → HCID 57431651, compound

HRID 545520Notes

Reaction equation

HRID 545520 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8]N)=[CH:4][C:3]=1[F:10].O=[C:12]1[CH2:17][CH2:16][CH:15]([NH:18][C:19](=[O:23])[CH:20]([CH3:22])[CH3:21])[CH2:14][CH2:13]1>>[Br:1][C:2]1[CH:7]=[C:6]2[C:5](=[CH:4][C:3]=1[F:10])[NH:8][C:12]1[CH2:17][CH2:16][CH:15]([NH:18][C:19](=[O:23])[CH:20]([CH3:21])[CH3:22])[CH2:14][C:13]2=1

Participants

3

Reactant 2

HCID 12149225(4-Bromo-3-fluorophenyl)hydrazineHCID 215339942-Methyl-N-(4-oxocyclohexyl)propanamide

Product 1

HCID 57431651HCID 57431651, compound

Procedure

Prepare the title compounds by essentially following the procedure as described in Preparation 4 (Method 2) with (4-bromo-3-fluoro-phenyl)-hydrazine (Preparation 12) and N-(4-oxo-cyclohexyl)-isobutyramide, to obtain a tan solid containing a 65:35 mixture of isomers in 20% overall yield. MS (ES): m/z 353, 355 (M+H), 351, 353 (M−H); HPLC (Method A): Rt=2.22 min, (95%).

Workup

  1. customto obtain a tan solid
  2. additioncontaining
  3. additiona 65:35 mixture of isomers in 20% overall yield

Sources & evidence

ORD record
ord-2216c89422e34bb793a5269e0a1e6f7a
Source dataset
uspto-grants-2011_05
Patent number
US07935722B2

Reaction notes

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