HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorobenzyl bromide → N-[6-Bromo-8-fluoro-9-(3-fluoro-benzyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]-isobutyramide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorobenzyl bromide | HCID 68007 | — |
| Reactant | N-(6-Bromo-8-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)-isobutyramide | HCID 57431654 | — |
| Product | N-[6-Bromo-8-fluoro-9-(3-fluoro-benzyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]-isobutyramide | HCID 59161271 | 36% |
Reaction Steps
Prepare the title compound by essentially following the procedure as described in Example 96 with N-(6-bromo-8-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-yl)-isobutyramide (Preparation 19) and 3-fluorobenzyl bromide, to obtain the title compound as a white solid in 36% yield. MS (ES): m/z 461,463 (M+1), 459, 461 (M−1); HPLC (Method A): Rt=4.60 (92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935722B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-098581a6e2ad4439880c1c0e8692d259 |
| Source note | uspto-grants-2011_05 |