(6-Bromo-3-fluoropyridin-2-yl)methanol → (3-Fluoropyridin-2-yl)methanol

HRID 545557Notes

Reaction equation

HRID 545557 reaction equation
Br[C:2]1[N:7]=[C:6]([CH2:8][OH:9])[C:5]([F:10])=[CH:4][CH:3]=1>CO>[F:10][C:5]1[C:6]([CH2:8][OH:9])=[N:7][CH:2]=[CH:3][CH:4]=1

Participants

3

Reactant 1

HCID 53485567(6-Bromo-3-fluoropyridin-2-yl)methanol

Product 1

HCID 19703803(3-Fluoropyridin-2-yl)methanol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Dissolve (6-bromo-3-fluoro-pyridin-2-yl)-methanol (850 mg, 4.13 mmol) in methanol (40 mL) then purge the solution with nitrogen. Add palladium on carbon (200 mg of 5% wet) and stir the mixture under a hydrogen atmosphere (2 balloons) for 20 h. Filter the mixture through Celite® and wash the filter cake with methanol.

Workup

  1. customthen purge the solution with nitrogen
  2. filtrationFilter the mixture through Celite®
  3. washwash the filter cake with methanol

Sources & evidence

ORD record
ord-a9b186df686f47e8baf5cb6124ab1aa7
Source dataset
uspto-grants-2011_05
Patent number
US07935722B2

Reaction notes

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