(6-Bromo-3-fluoropyridin-2-yl)methanol → (3-Fluoropyridin-2-yl)methanol

Participants

Reaction Steps

Dissolve (6-bromo-3-fluoro-pyridin-2-yl)-methanol (850 mg, 4.13 mmol) in methanol (40 mL) then purge the solution with nitrogen. Add palladium on carbon (200 mg of 5% wet) and stir the mixture under a hydrogen atmosphere (2 balloons) for 20 h. Filter the mixture through Celite® and wash the filter cake with methanol.

Provenance & Evidence