HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorobenzyl bromide → Cyclopropanecarboxylic acid[6-cyano-9-(3-fluorobenzyl)-2,3,4,9-tetrahydro-1h-carbazol-3-yl]amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorobenzyl bromide | HCID 68007 | — |
| Reactant | Cyclopropanecarboxylic acid(6-cyano-2,3,4,9-tetrahydro-1h-carbazol-3-yl)amide | HCID 59161240 | — |
| Product | Cyclopropanecarboxylic acid[6-cyano-9-(3-fluorobenzyl)-2,3,4,9-tetrahydro-1h-carbazol-3-yl]amide | HCID 59161234 | — |
Reaction Steps
Prepare the title compound from cyclopropanecarboxylic acid(6-cyano-2,3,4,9-tetrahydro-1H-carbazol-3-yl)amide (3.00 g, 10.7 mmol) and 3-fluorobenzyl bromide (2.2 g, 11.8 mmol) by essentially following procedures as described in Example 1 to obtain 1.4 g (34%) of a beige solid. mp: 207-209° C.; MS (ES): m/z 388 (M+1); HPLC: Rt=2.28 min (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935722B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-026598d62ea74297b89b64d20cdd34ea |
| Source note | uspto-grants-2011_05 |