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HRID545581

反应详情

EQUATION

反应方程式

HRID 545581 的结构方程式

REACTANTS

反应物

2
结构：C#CC
HCID6335

1-Propyne

C3H4

结构：O=C(N[C@@H]1CCc2c(c3cc(C=NO)ccc3n2Cc2cccc(F)c2)C1)C1CC1
HCID87305657

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(-c2ccc3c(c2)c2c(n3Cc3cccc(F)c3)CC[C@@H](NC(=O)C3CC3)C2)no1
HCID59161297

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

结构：[Na+].[O-]Cl
溶剂HCID23665760

Sodium Hypochlorite

ClNaO

CONDITIONS

反应条件

温度
23 °C

PROCEDURE

实验过程

Bubble propyne gas through a solution of (R)-cyclopropanecarboxylic acid[9-(3-fluoro-benzyl)-6-(hydroxyimino-methyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]-amide (Example 203) (0.065 g, 0.16 mmol) in methylene chloride and NaOCl solution maintained in a sealed tube. Cap the tube and stir at 23° C. for 16 h. Partition the reaction between methylene chloride and water. Separate and dry the organic portion over Na2SO4 to give 0.045 g of a tan solid. Purify by silca gel chromatography, eluting with 20-80% EtOAc/gradient to give an 0.030g (42%) of an off-white solid. mp: 190-192° C.; MS (ES): m/z 444 (M+1).

WORKUP

后处理

  1. temperaturemaintained in a sealed tube
  2. customCap the tube
  3. customPartition
  4. customthe reaction between methylene chloride and water
  5. customSeparate
  6. dry with materialdry the organic portion over Na2SO4