HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → (r)-Cyclopropanecarboxylic acid[9-(3-fluoro-benzyl)-6-(1-methoxyimino-methyl)-2,3,4,9-tetrahydro-1h-carbazol-3-yl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| Reactant | (r)-Cyclopropanecarboxylic acid[9-(3-fluorobenzyl)-6-formyl-2,3,4,9-tetrahydro-1h-carbazol-3-yl]-amide | HCID 59161221 | — |
| Product | (r)-Cyclopropanecarboxylic acid[9-(3-fluoro-benzyl)-6-(1-methoxyimino-methyl)-2,3,4,9-tetrahydro-1h-carbazol-3-yl]-amide | HCID 87305428 | — |
Reaction Steps
Prepare the title compound from (R)-cyclopropanecarboxylic acid[9-(3-fluorobenzyl)-6-formyl-2,3,4,9-tetrahydro-1H-carbazol-3-yl]-amide (Preparation 71) (3.10 g, 7.94 mmol), methoxylamine hydrochloride (1.99 g, 23.8 mmol), and sodium hydroxide (0.48 g, 11.9 mmol) by essentially following procedures as described in Example 204. Purify using silica gel chromatography eluting with 10% EtOAc/CH2Cl2 to provide 1.94 g (58%) of product. mp: 200-203° C.; MS (ES) m/z 420 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935722B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-930b48ac19394997802356f00d21f9a8 |
| Source note | uspto-grants-2011_05 |