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HRID545582

反应详情

EQUATION

反应方程式

HRID 545582 的结构方程式

REACTANTS

反应物

3
结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：CON.Cl
HCID521874

O-Methylhydroxylamine hydrochloride

CH6ClNO

结构：O=Cc1ccc2c(c1)c1c(n2Cc2cccc(F)c2)CC[C@@H](NC(=O)C2CC2)C1
HCID59161221

(r)-Cyclopropanecarboxylic acid[9-(3-fluorobenzyl)-6-formyl-2,3,4,9-tetrahydro-1h-carbazol-3-yl]-amide

C24H23FN2O2

PRODUCTS

生成物

1
结构：CON=Cc1ccc2c(c1)c1c(n2Cc2cccc(F)c2)CC[C@@H](NC(=O)C2CC2)C1
HCID87305428

未命名化合物

PROCEDURE

实验过程

Prepare the title compound from (R)-cyclopropanecarboxylic acid[9-(3-fluorobenzyl)-6-formyl-2,3,4,9-tetrahydro-1H-carbazol-3-yl]-amide (Preparation 71) (3.10 g, 7.94 mmol), methoxylamine hydrochloride (1.99 g, 23.8 mmol), and sodium hydroxide (0.48 g, 11.9 mmol) by essentially following procedures as described in Example 204. Purify using silica gel chromatography eluting with 10% EtOAc/CH2Cl2 to provide 1.94 g (58%) of product. mp: 200-203° C.; MS (ES) m/z 420 (M+1).