HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylvinyltin → 3-Ethenyl-5-fluoropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylvinyltin | HCID 81998 | — |
| Reactant | 3-Bromo-5-fluoropyridine | HCID 820206 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Ethenyl-5-fluoropyridine | HCID 57416843 | — |
Reaction Steps
A mixture of 7.0 g (0.04 mole) 3-fluoro-5-bromopyridine, 15.3 g (0.048 mole) tributyl(vinyl)stannane, 2.5 g (0.002 mole) tetrakis(triphenylphosphine)palladium in 70 ml toluene was boiled with reflux during 16 hours. Toluene was evaporated with a 30 cm column. The residue was fractionated twice.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935823B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-f5a454fae301499c90b5d8d45d8e49d5 |
| Source note | uspto-grants-2011_05 |