反应详情

67.5 g (0.41 mol)3-acetamidoanisol are suspended in 200 ml 1,2-dichloroethane and cooled in an ice bath. 217 g (1.64 mol) AlCl3 and after it 38.5 g (0.49 mol) acetylchloride were added successively. Stirring was continued 1/2 hour. After 5 hours the reaction was quenched with ice and ethylacetate and water were added. The organic layer was seperated, washed with water, dried over MgSO4 and concentrated in vacuo. The residue was recrystallized from dioxane and water.

1. temperaturecooled in an ice bath
2. customAfter 5 hours the reaction was quenched with ice and ethylacetate and water
3. additionwere added
4. customThe organic layer was seperated
5. washwashed with water
6. dry with materialdried over MgSO4
7. concentrationconcentrated in vacuo
8. customThe residue was recrystallized from dioxane and water