反应详情

To a suspension of 5-[3-(amino)propyloxy]imidazo[1,2-a]pyridine dihydrochloride (2.64 g, 10 mmoles) and triethylamine (4.88 ml, 35 mmoles) in methylene chloride (100 ml)-acetonitrile (30 ml) was added benzenesulfonyl chloride (1.53 ml, 12 mmoles) under ice-cooling with stirring and the mixture was stirred at room temperature for 1 hour. The reaction mixture was washed in turn with an aqueous sodium bicarbonate solution and saturated saline and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the crude product thus obtained was recrystallized from methylene-ethanol to obtain 1.97 g of the desired product (59.5%, light brown crystals).

1. temperaturecooling
2. stirringthe mixture was stirred at room temperature for 1 hour
3. washThe reaction mixture was washed in turn with an aqueous sodium bicarbonate solution and saturated saline
4. dry with materialdried over anhydrous magnesium sulfate
5. distillationAfter the solvent was distilled off
6. customthe crude product thus obtained
7. customwas recrystallized from methylene-ethanol