反应详情

To a solution of 5-[3-(hydroxy)propylthio]imidazo[1,2-a]pyridine (2.00 g, 9.60 mmoles) and triethylamine (1.60 ml, 11.5 mmoles) in methylene chloride (50 ml) was added acetic anhydride (1.10 ml, 11.6 mmoles) with stirring at room temperature and the mixture was further stirred at room temperature for 7.5 hours. The reaction mixture was washed with an aqueous 1N sodium hydroxide solution and dried. After the solvent was distilled off, the residue was purified by column chromatography [eluent: hexane/acetone (1:1)] to obtain 2.40 g of the desired product (100%, brown oily product).

1. stirringthe mixture was further stirred at room temperature for 7.5 hours
2. washThe reaction mixture was washed with an aqueous 1N sodium hydroxide solution
3. customdried
4. distillationAfter the solvent was distilled off
5. customthe residue was purified by column chromatography [eluent: hexane/acetone (1:1)]