1-(3-Nitro-pyrazol-1-yl)-propan-2-ol → 1-(3-amino-1H-pyrazol-1-yl)propan-2-ol

HRID 546133Notes

Reaction equation

HRID 546133 reaction equation
[N+:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9][CH:10]([OH:12])[CH3:11])[N:5]=1)([O-])=O.[H][H]>[Pd].C(O)C>[NH2:1][C:4]1[CH:8]=[CH:7][N:6]([CH2:9][CH:10]([OH:12])[CH3:11])[N:5]=1

Participants

5

Reactant 2

HCID 611777651-(3-Nitro-pyrazol-1-yl)-propan-2-olHCID 178418361HCID 178418361, compound

Product 1

HCID 552846691-(3-amino-1H-pyrazol-1-yl)propan-2-olYield 96%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

In a Parr shaker bottle was placed 1-(3-nitro-pyrazol-1-yl)-propan-2-ol (58 mg, 0.34 mmol), 10% palladium on activated carbon (12 mg) and ethanol (5 mL). The bottle was then placed on the Parr shaker at 50 psi of hydrogen pressure for 1 h. The reaction was then filtered through a pad of celite and washed with ethanol and concentration in vacuo afforded 1-(3-amino-pyrazol-1-yl)-propan-2-ol (46 mg, 96%) as a clear colorless oil and taken on to the next step without characterization.

Workup

  1. filtrationThe reaction was then filtered through a pad of celite
  2. washwashed with ethanol and concentration in vacuo

Sources & evidence

ORD record
ord-54cd9e511d654cf5b89035e2a131ca2d
Source dataset
uspto-grants-2011_05
Patent number
US07935699B2

Reaction notes

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