1-(3-Nitro-pyrazol-1-yl)-propan-2-ol → 1-(3-amino-1H-pyrazol-1-yl)propan-2-ol

Participants

Reaction Steps

In a Parr shaker bottle was placed 1-(3-nitro-pyrazol-1-yl)-propan-2-ol (58 mg, 0.34 mmol), 10% palladium on activated carbon (12 mg) and ethanol (5 mL). The bottle was then placed on the Parr shaker at 50 psi of hydrogen pressure for 1 h. The reaction was then filtered through a pad of celite and washed with ethanol and concentration in vacuo afforded 1-(3-amino-pyrazol-1-yl)-propan-2-ol (46 mg, 96%) as a clear colorless oil and taken on to the next step without characterization.

Provenance & Evidence