反应详情

温度

65 °C

In a round bottom flask was placed (2,3-dihydro-benzo[b]thiophen-5-yl)-acetic acid (525 mg, 2.70 mmol), methanol (15 mL) and hydrochloric acid (2 drops). The reaction mixture was heated to 65° C. for 16 h. It was then concentrated in vacuo to remove the methanol, diluted with water (20 mL) and extracted with ethyl acetate (3×20 mL). The organic layers were combined and washed with a saturated aqueous sodium bicarbonate solution (10 mL), dried over magnesium sulfate, filtered and concentrated in vacuo to afford (2,3-dihydro-benzo[b]thiophen-5-yl)-acetic acid methyl ester (528 mg, 94%) as a yellow oil: ES-HRMS m/e calcd for C11H12O2S (M+H)+ 209.0631, observed 209.0631.

1. customIn a round bottom flask was placed
2. concentrationIt was then concentrated in vacuo
3. customto remove the methanol
4. additiondiluted with water (20 mL)
5. extractionextracted with ethyl acetate (3×20 mL)
6. washwashed with a saturated aqueous sodium bicarbonate solution (10 mL)
7. dry with materialdried over magnesium sulfate
8. filtrationfiltered
9. concentrationconcentrated in vacuo