反应详情

温度

90 °C

(4-Hydroxy-phenoxy)-acetic acid methyl ester 11 (20 grams, 109.89 mmol) is added to 10% sodium hydroxide solution (100 mL) and heated to 90° C. on water bath for 6 hours. The reaction mixture is cooled to room temperature, and the pH is adjusted to 2 with distilled HCl. Crude 12, is filtered, dried, and can be recrystallised in appropriate solvent.

1. temperatureThe reaction mixture is cooled to room temperature
2. filtrationCrude 12, is filtered
3. customdried
4. customcan be recrystallised in appropriate solvent