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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 546440Generated: October 31, 2026

Water → HCID 23712813, compound

https://huagongshe.com/reaction/546440

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantLithium HydroxideHCID 3939—
ReactantEthyl 1-isopropylpiperidine-4-carboxylateHCID 19900430—
SolventTetrahydrofuranHCID 8028—
ProductHCID 23712813HCID 23712813100%

Reaction Steps

Ethyl 1-isopropylpiperidine-4-carboxylate (Farmaco., 1993, Vol. 48, p. 1439) (3.43 g) was dissolved in tetrahydrofuran (60 ml), and water (15 ml) and lithium hydroxide (421 mg) were added at room temperature to stir the mixture overnight. The reaction mixture was concentrated under reduced pressure to obtain the title compound (3.05 g) as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07935824B2
Source datasetuspto-grants-2011_05
ORD IDord-fd84500ac5724f2d998a5236c197f6d9
Source noteuspto-grants-2011_05