Water → HCID 23712813, compound

HRID 546440Notes

Reaction equation

HRID 546440 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]([O:12]CC)=[O:11])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].O.[OH-].[Li+:17]>O1CCCC1>[CH:1]([N:4]1[CH2:5][CH2:6][CH:7]([C:10]([O-:12])=[O:11])[CH2:8][CH2:9]1)([CH3:3])[CH3:2].[Li+:17]

Participants

5

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 19900430Ethyl 1-isopropylpiperidine-4-carboxylate

Product 1

HCID 23712813HCID 23712813, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ethyl 1-isopropylpiperidine-4-carboxylate (Farmaco., 1993, Vol. 48, p. 1439) (3.43 g) was dissolved in tetrahydrofuran (60 ml), and water (15 ml) and lithium hydroxide (421 mg) were added at room temperature to stir the mixture overnight. The reaction mixture was concentrated under reduced pressure to obtain the title compound (3.05 g) as a white solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-fd84500ac5724f2d998a5236c197f6d9
Source dataset
uspto-grants-2011_05
Patent number
US07935824B2

Reaction notes

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