Lithium Hydroxide → HCID 58822249, compound

HRID 546514Notes

Reaction equation

HRID 546514 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[CH:14]=[N:13][C:12]([C:17]([O:19]C)=O)=[N:11][C:10]=2[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Li+].Cl.[Cl:24][C:25]1[CH:26]=[C:27]2[C:31](=[CH:32][CH:33]=1)[NH:30][C:29]([C:34]([NH:36][C@@H:37]1[CH2:42][CH2:41][CH2:40][CH2:39][C@@H:38]1[NH2:43])=[O:35])=[CH:28]2>>[C:1]([O:5][C:6]([N:8]1[CH2:16][C:15]2[CH:14]=[N:13][C:12]([C:17]([NH:43][C@@H:38]3[CH2:39][CH2:40][CH2:41][CH2:42][C@@H:37]3[NH:36][C:34]([C:29]3[NH:30][C:31]4[C:27]([CH:28]=3)=[CH:26][C:25]([Cl:24])=[CH:33][CH:32]=4)=[O:35])=[O:19])=[N:11][C:10]=2[CH2:9]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 3

HCID 3939Lithium HydroxideHCID 184428206-(1,1-Dimethylethyl) 2-methyl 5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-2,6-dicarboxylateHCID 18442849HCID 18442849, compound

Product 1

HCID 58822249HCID 58822249, compound

Procedure

After 6-(tert-Butoxycarbonyl)-5,7-dihydro-2-methoxycarbonylpyrrolo[3,4-d]pyrimidine was hydrolyzed with lithium hydroxide, it was reacted with (±)-cis-N-[(5-chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine hydrochloride in a similar manner to Example 2 to obtain the title compound.

Sources & evidence

ORD record
ord-0a402eec8194459e9c16d3209f880dab
Source dataset
uspto-grants-2011_05
Patent number
US07935824B2

Reaction notes

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