Hydrochloric Acid → HCID 58822199, compound

HRID 546524Notes

Reaction equation

HRID 546524 reaction equation
C(O[C:6]([NH:8][C@@H:9]1[CH2:14][C@@H:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:12][CH2:11][C@H:10]1[NH:20][C:21]([C:23]1[NH:24][C:25]2[C:30]([CH:31]=1)=[CH:29][C:28]([Cl:32])=[CH:27][CH:26]=2)=[O:22])=[O:7])(C)(C)C.Cl.[CH3:34][N:35]1[CH2:40][CH2:39][C:38]2[N:41]=[C:42](C([O-])=O)[S:43][C:37]=2[CH2:36]1.[Li+]>C(O)C>[Cl:32][C:28]1[CH:29]=[C:30]2[C:25](=[CH:26][CH:27]=1)[NH:24][C:23]([C:21]([NH:20][C@@H:10]1[CH2:11][CH2:12][C@H:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:14][C@H:9]1[NH:8][C:6]([C:42]1[S:43][C:37]3[CH2:36][N:35]([CH3:34])[CH2:40][CH2:39][C:38]=3[N:41]=1)=[O:7])=[O:22])=[CH:31]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 23704331Lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylateHCID 58822150HCID 58822150, compound

Product 1

HCID 58822199HCID 58822199, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(1R*,2R*,4S*)-N2-tert-Butoxycarbonyl-N1-[(5-chloroindol-2-yl)carbonyl]-4-ethoxycarbonyl-1,2-cyclohexanediamine was treated with a saturated ethanol solution of hydrochloric acid and then condensed with lithium 5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]-pyridine-2-carboxylate in a similar manner to Example 118 to obtain the title compound.

Sources & evidence

ORD record
ord-a2dfc4da7a7c4fc68270b742ee9910a0
Source dataset
uspto-grants-2011_05
Patent number
US07935824B2

Reaction notes

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