Hydrochloric Acid → HCID 59676849, compound

HRID 546526Notes

Reaction equation

HRID 546526 reaction equation
C([O:5][C:6]([NH:8][C@H:9]1[CH2:14][C@H:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:12][CH2:11][C@H:10]1[NH:20][C:21]([C:23]1[S:24][C:25]2[CH2:26][N:27]([CH3:32])[CH2:28][CH2:29][C:30]=2[N:31]=1)=[O:22])=O)(C)(C)C.Cl.[Cl:34][C:35]1[CH:36]=[C:37]2[C:41](=[CH:42][CH:43]=1)[NH:40][C:39](C(O)=O)=[CH:38]2>C(O)C>[Cl:34][C:35]1[CH:36]=[C:37]2[C:41](=[CH:42][CH:43]=1)[NH:40][C:39]([C:6]([NH:8][C@H:9]1[CH2:14][C@H:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:12][CH2:11][C@H:10]1[NH:20][C:21]([C:23]1[S:24][C:25]3[CH2:26][N:27]([CH3:32])[CH2:28][CH2:29][C:30]=3[N:31]=1)=[O:22])=[O:5])=[CH:38]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 826935-Chloro-1H-indole-2-carboxylic acidHCID 58822131HCID 58822131, compound

Product 1

HCID 59676849HCID 59676849, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(1R*,2S*,4R*)-N2-tert-Butoxycarbonyl-4-ethoxycarbonyl-N1-[(5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine was treated with a saturated ethanol solution of hydrochloric acid and then condensed with 5-chloroindole-2-carboxylic acid in a similar manner to Example 118 to obtain the title compound.

Sources & evidence

ORD record
ord-17c7b0334148432b8f90cb934eda114e
Source dataset
uspto-grants-2011_05
Patent number
US07935824B2

Reaction notes

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