Hydrochloric Acid → HCID 57864675, compound

HRID 546530Notes

Reaction equation

HRID 546530 reaction equation
C([O:5][C:6]([NH:8][C@@H:9]1[CH2:14][C@@H:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:12][CH2:11][C@@H:10]1[NH:20][C:21]([C:23]1[NH:24][C:25]2[C:30]([CH:31]=1)=[CH:29][C:28]([F:32])=[CH:27][CH:26]=2)=[O:22])=O)(C)(C)C.Cl.[CH3:34][N:35]1[CH2:40][CH2:39][C:38]2[N:41]=[C:42](C([O-])=O)[S:43][C:37]=2[CH2:36]1.[Li+]>O1CCOCC1>[CH2:18]([O:17][C:15]([C@H:13]1[CH2:12][CH2:11][C@H:10]([NH:20][C:21]([C:23]2[NH:24][C:25]3[C:30]([CH:31]=2)=[CH:29][C:28]([F:32])=[CH:27][CH:26]=3)=[O:22])[C@H:9]([NH:8][C:6]([C:42]2[S:43][C:37]3[CH2:36][N:35]([CH3:34])[CH2:40][CH2:39][C:38]=3[N:41]=2)=[O:5])[CH2:14]1)=[O:16])[CH3:19]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 23704331Lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylateHCID 58822205HCID 58822205, compound

Product 1

HCID 57864675HCID 57864675, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(1S,2R,4S)—N2-tert-Butoxycarbonyl-4-ethoxycarbonyl-N1-[(5-fluoroindol-2-yl)carbonyl]-1,2-cyclohexanediamine was treated with a 4N dioxane solution of hydrochloric acid and then condensed with lithium 5-methyl-4,5,6,7-tetrahydrothiazolo-[5,4-c]pyridine-2-carboxylate in a similar manner to Example 118 to obtain the title compound.

Sources & evidence

ORD record
ord-26e5a8d4fc5549caaa0893690bf630b8
Source dataset
uspto-grants-2011_05
Patent number
US07935824B2

Reaction notes

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